Symbol: Name: ID: |
RNF139 ring finger protein 139 GFS:6115 |
Gene name: | RNF139 |
Chromosome: | 8q24 |
Previous Symbols: | |
Previous Names: | |
Aliases: | TRC8, RCA1, HRCA1 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1923091 | Rat Genome Database ID: | RGD:1306670 |
HGNC ID: | HGNC:17023 | RefSeq IDs: | NM_007218 |
Entrez Gene ID: | 11236 | Ensembl Gene ID: | ENSG00000170881 |
VEGA IDs: | UniProt ID: | Q8WU17 | |
UCSC ID: | uc003yrc.2 | OMIM ID: | 603046 |
Pubmed: | PMID9689122 | ||
CCDS IDs: | CCDSCCDS6350.1 |
RING finger protein 139 is a protein that in humans is encoded by the RNF139 gene.
The protein encoded by this gene is a multi-membrane spanning protein containing a RING-H2 finger. This protein is located in the endoplasmic reticulum, and has been shown to possess ubiquitin ligase activity. This gene was found to be interrupted by a t(3:8) translocation in a family with hereditary renal and non-medulary thyroid cancer. Studies of the Drosophila counterpart suggested that this protein may interact with tumor suppressor protein VHL, as well as with COPS5/JAB1, a protein responsible for the degradation of tumor suppressor CDKN1B/P27KIP. [provided by RefSeq, Jul 2008].
Function: E3-ubiquitin ligase; acts as a negative regulator of the cell proliferation through mechanisms involving G2/M arrest and cell death. Required for MHC class I ubiquitination in cells expressing the cytomegalovirus protein US2 before dislocation from the endoplasmic reticulum (ER). Affects SREBP processing by hindering the SREBP/SCAP complex translocation from the ER to the Golgi, thereby reducing SREBF2 target gene expression. Required for INSIG1 ubiquitination. May be required for EIF3 complex ubiquitination. May function as a signaling receptor.
Products for RNF139 gene
Catalog | Product Name | Application | Company |
GFS:E06115 | ring finger protein 139; ELISA kit | ELISA | n/a |
GFS:A06115 | ring finger protein 139; Anti | ANTIBODIES | n/a |
GFS:P06115 | ring finger protein 139; Protien | Protien | n/a |