Symbol: Name: ID: |
RNF111 ring finger protein 111 GFS:6462 |
Gene name: | RNF111 |
Chromosome: | 15q21 |
Previous Symbols: | |
Previous Names: | |
Aliases: | ARK, Arkadia, FLJ38008, DKFZP761D081 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1934919 | Rat Genome Database ID: | RGD:1310097 |
HGNC ID: | HGNC:17384 | RefSeq IDs: | NM_017610 |
Entrez Gene ID: | 54778 | Ensembl Gene ID: | ENSG00000157450 |
VEGA IDs: | OTTHUMG00000132716 | UniProt ID: | Q6ZNA4 |
UCSC ID: | uc002afs.2 | OMIM ID: | 605840 |
Pubmed: | PMID11298452 | ||
CCDS IDs: | CCDSCCDS10169.1 |
E3 ubiquitin-protein ligase Arkadia is an enzyme that in humans is encoded by the RNF111 gene.
The protein encoded by this gene contains a RING finger domain, a motif known to be involved in protein-protein and protein-DNA interactions. The mouse counterpart of this gene (Rnf111/arkadia) has been shown to genetically interact with the transforming growth factor (TGF) beta-like factor Nodal, and act as a modulator of the nodal signaling cascade, which is essential for the induction of mesoderm during embryonic development. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Function: Acts in the NODAL pathway of mesoderm patterning during embryonic development. Acts downstream AXIN1 as an E3 ubiquitin-protein ligase which promotes the ubiquitination of inhibitory SMADs such as SMAD7, induces their proteasomal degradation and thereby enhances the transcriptional activity of TGF-beta and BMP. Activates Smad3/Smad4-dependent transcription by triggering signal-induced SnoN degradation.
Products for RNF111 gene
Catalog | Product Name | Application | Company |
GFS:E06462 | ring finger protein 111; ELISA kit | ELISA | n/a |
GFS:A06462 | ring finger protein 111; Anti | ANTIBODIES | n/a |
GFS:P06462 | ring finger protein 111; Protien | Protien | n/a |