Symbol: Name: ID: |
RGS18 regulator of G-protein signaling 18 GFS:3627 |
Gene name: | RGS18 |
Chromosome: | 1q31.2 |
Previous Symbols: | |
Previous Names: | regulator of G-protein signalling 18 |
Aliases: | RGS13 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1927498 | Rat Genome Database ID: | RGD:1306522 |
HGNC ID: | HGNC:14261 | RefSeq IDs: | NM_130782 |
Entrez Gene ID: | 64407 | Ensembl Gene ID: | ENSG00000150681 |
VEGA IDs: | OTTHUMG00000035592 | UniProt ID: | Q9NS28 |
UCSC ID: | uc001gsg.2 | OMIM ID: | 607192 |
Pubmed: | PMID11042171 | ||
CCDS IDs: | CCDSCCDS1374.1 |
Regulator of G-protein signaling 18 is a protein that in humans is encoded by the RGS18 gene.
This gene encodes a member of the regulator of G-protein signaling family. This protein is contains a conserved, 120 amino acid motif called the RGS domain. The protein attenuates the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Function: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i) alpha-1, G(i) alpha-2, G(i) alpha-3 and G(q) alpha.
Products for RGS18 gene
Catalog | Product Name | Application | Company |
GFS:E03627 | regulator of G-protein signaling 18; ELISA kit | ELISA | n/a |
GFS:A03627 | regulator of G-protein signaling 18; Anti | ANTIBODIES | n/a |
GFS:P03627 | regulator of G-protein signaling 18; Protien | Protien | n/a |