Symbol: Name: ID: |
RGS17 regulator of G-protein signaling 17 GFS:3510 |
Gene name: | RGS17 |
Chromosome: | 6q25-q26 |
Previous Symbols: | |
Previous Names: | regulator of G-protein signalling 17 |
Aliases: | RGSZ2, RGS-17 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1927469 | Rat Genome Database ID: | RGD:1305515 |
HGNC ID: | HGNC:14088 | RefSeq IDs: | NM_012419 |
Entrez Gene ID: | 26575 | Ensembl Gene ID: | ENSG00000091844 |
VEGA IDs: | OTTHUMG00000015858 | UniProt ID: | Q9UGC6 |
UCSC ID: | uc003qpm.2 | OMIM ID: | 607191 |
Pubmed: | PMID10419452 | ||
CCDS IDs: | CCDSCCDS5244.1 |
Regulator of G-protein signaling 17 is a protein that in humans is encoded by the RGS17 gene.
This gene encodes a member of the regulator of G-protein signaling family. This protein contains a conserved, 120 amino acid motif called the RGS domain and a cysteine-rich region. The protein attenuates the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Function: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds selectively to G(z)-alpha and G(alpha)-i2 subunits, accelerates their GTPase activity and regulates their signaling activities. The G(z)-alpha activity is inhibited by the phosphorylation and palmitoylation of the G-protein. Negatively regulates mu-opioid receptor-mediated activation of the G-proteins (By similarity).
Products for RGS17 gene
Catalog | Product Name | Application | Company |
GFS:E03510 | regulator of G-protein signaling 17; ELISA kit | ELISA | n/a |
GFS:A03510 | regulator of G-protein signaling 17; Anti | ANTIBODIES | n/a |
GFS:P03510 | regulator of G-protein signaling 17; Protien | Protien | n/a |