Symbol: Name: ID: |
HDAC8 histone deacetylase 8 GFS:2941 |
Gene name: | HDAC8 |
Chromosome: | Xq13 |
Previous Symbols: | HDACL1 |
Previous Names: | histone deacetylase-like 1 |
Aliases: | RPD3 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1917565 | Rat Genome Database ID: | RGD:1562895 |
HGNC ID: | HGNC:13315 | RefSeq IDs: | NM_001166418 |
Entrez Gene ID: | 55869 | Ensembl Gene ID: | ENSG00000147099 |
VEGA IDs: | OTTHUMG00000021814 | UniProt ID: | Q9BY41 |
UCSC ID: | uc004eau.2 | OMIM ID: | 300269 |
Pubmed: | PMID10756090 PMID 10922473 | ||
CCDS IDs: | CCDSCCDS14420.1 |
Histone deacetylase 8 is an enzyme that in humans is encoded by the HDAC8 gene, and is biologically involved in skull morphogenesis and metabolic control of the ERR-alpha/PGC1-alpha transcriptional complex.
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class I of the histone deacetylase family. It catalyzes the deacetylation of lysine residues in the histone N-terminal tails and represses transcription in large multiprotein complexes with transcriptional co-repressors. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].
Function: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. May play a role in smooth muscle cell contractility.
Products for HDAC8 gene
Catalog | Product Name | Application | Company |
GFS:E02941 | histone deacetylase 8; ELISA kit | ELISA | n/a |
GFS:A02941 | histone deacetylase 8; Anti | ANTIBODIES | n/a |
GFS:P02941 | histone deacetylase 8; Protien | Protien | n/a |