Symbol: Name: ID: |
HDAC7 histone deacetylase 7 GFS:3493 |
Gene name: | HDAC7 |
Chromosome: | 12q13.1 |
Previous Symbols: | HDAC7A |
Previous Names: | histone deacetylase 7A |
Aliases: | DKFZP586J0917 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1891835 | Rat Genome Database ID: | RGD:619982 |
HGNC ID: | HGNC:14067 | RefSeq IDs: | NM_001098416 |
Entrez Gene ID: | 51564 | Ensembl Gene ID: | ENSG00000061273 |
VEGA IDs: | OTTHUMG00000152968 | UniProt ID: | Q8WUI4 |
UCSC ID: | uc010slo.1 | OMIM ID: | 606542 |
Pubmed: | PMID10922406 PMID 10640276 | ||
CCDS IDs: | CCDSCCDS8756.2 CCDS CCDS41776.1 |
Histone deacetylase 7 is an enzyme that in humans is encoded by the HDAC7 gene.
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene has sequence homology to members of the histone deacetylase family. This gene is orthologous to mouse HDAC7 gene whose protein promotes repression mediated via the transcriptional corepressor SMRT. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Function: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer factors such as MEF2A, MEF2B and MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors (By similarity). May be involved in Epstein-Barr virus (EBV) latency, possibly by repressing the viral BZLF1 gene.
Products for HDAC7 gene
Catalog | Product Name | Application | Company |
GFS:E03493 | histone deacetylase 7; ELISA kit | ELISA | n/a |
GFS:A03493 | histone deacetylase 7; Anti | ANTIBODIES | n/a |
GFS:P03493 | histone deacetylase 7; Protien | Protien | n/a |