Symbol: Name: ID: |
HDAC4 histone deacetylase 4 GFS:3490 |
Gene name: | HDAC4 |
Chromosome: | 2q37.3 |
Previous Symbols: | |
Previous Names: | |
Aliases: | KIAA0288, HDAC-A, HDACA, HD4, HA6116 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:3036234 | Rat Genome Database ID: | RGD:619979 |
HGNC ID: | HGNC:14063 | RefSeq IDs: | NM_006037 |
Entrez Gene ID: | 9759 | Ensembl Gene ID: | ENSG00000068024 |
VEGA IDs: | OTTHUMG00000133344 | UniProt ID: | P56524 |
UCSC ID: | uc002vyk.3 | OMIM ID: | 605314 |
Pubmed: | PMID10206986 PMID 10220385 | ||
CCDS IDs: | CCDSCCDS2529.1 |
Histone deacetylase 4, also known as HDAC4, is a protein which in humans is encoded by the HDAC4 gene.
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Function: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D.
Products for HDAC4 gene
Catalog | Product Name | Application | Company |
GFS:E03490 | histone deacetylase 4; ELISA kit | ELISA | n/a |
GFS:A03490 | histone deacetylase 4; Anti | ANTIBODIES | n/a |
GFS:P03490 | histone deacetylase 4; Protien | Protien | n/a |