Symbol: Name: ID: |
HDAC5 histone deacetylase 5 GFS:3494 |
Gene name: | HDAC5 |
Chromosome: | 17q21 |
Previous Symbols: | |
Previous Names: | |
Aliases: | KIAA0600, NY-CO-9, FLJ90614 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1333784 | Rat Genome Database ID: | |
HGNC ID: | HGNC:14068 | RefSeq IDs: | NM_001015053 |
Entrez Gene ID: | 10014 | Ensembl Gene ID: | ENSG00000108840 |
VEGA IDs: | UniProt ID: | Q9UQL6 | |
UCSC ID: | uc002iff.1 | OMIM ID: | 605315 |
Pubmed: | PMID10220385 PMID 9610721 | ||
CCDS IDs: | CCDSCCDS32663.1 CCDS CCDS45696.1 |
Histone deacetylase 5 is an enzyme that in humans is encoded by the HDAC5 gene.
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the class II histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins. It also interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. This gene is thought to be associated with colon cancer. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Function: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors.
Products for HDAC5 gene
Catalog | Product Name | Application | Company |
GFS:E03494 | histone deacetylase 5; ELISA kit | ELISA | n/a |
GFS:A03494 | histone deacetylase 5; Anti | ANTIBODIES | n/a |
GFS:P03494 | histone deacetylase 5; Protien | Protien | n/a |