Symbol: Name: ID: |
CHRNA9 cholinergic receptor, nicotinic, alpha 9 GFS:3503 |
Gene name: | CHRNA9 |
Chromosome: | 4p14 |
Previous Symbols: | |
Previous Names: | cholinergic receptor, nicotinic, alpha polypeptide 9 |
Aliases: | NACHRA9 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1202403 | Rat Genome Database ID: | RGD:621534 |
HGNC ID: | HGNC:14079 | RefSeq IDs: | NM_017581 |
Entrez Gene ID: | 55584 | Ensembl Gene ID: | ENSG00000174343 |
VEGA IDs: | OTTHUMG00000099375 | UniProt ID: | Q9UGM1 |
UCSC ID: | uc003gva.1 | OMIM ID: | 605116 |
Pubmed: | |||
CCDS IDs: | CCDSCCDS3459.1 |
Neuronal acetylcholine receptor subunit alpha-9 is a protein that in humans is encoded by the CHRNA9 gene.
This gene is a member of the ligand-gated ionic channel family and nicotinic acetylcholine receptor gene superfamily. It encodes a plasma membrane protein that forms homo- or hetero-oligomeric divalent cation channels. This protein is involved in cochlea hair cell development and is also expressed in the outer hair cells (OHCs) of the adult cochlea. The protein is additionally expressed in keratinocytes, the pituitary gland, B-cells and T-cells. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Function: Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding may induce an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane. In the ear, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma. May also regulate keratinocyte adhesion.
Products for CHRNA9 gene
Catalog | Product Name | Application | Company |
GFS:E03503 | cholinergic receptor, nicotinic, alpha 9; ELISA kit | ELISA | n/a |
GFS:A03503 | cholinergic receptor, nicotinic, alpha 9; Anti | ANTIBODIES | n/a |
GFS:P03503 | cholinergic receptor, nicotinic, alpha 9; Protien | Protien | n/a |