Symbol: Name: ID: |
CAPN6 calpain 6 GFS:4116 |
Gene name: | CAPN6 |
Chromosome: | Xq23 |
Previous Symbols: | |
Previous Names: | |
Aliases: | CAPNX, CalpM, CANPX |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1100850 | Rat Genome Database ID: | RGD:70960 |
HGNC ID: | HGNC:1483 | RefSeq IDs: | NM_014289 |
Entrez Gene ID: | 827 | Ensembl Gene ID: | ENSG00000077274 |
VEGA IDs: | OTTHUMG00000022203 | UniProt ID: | Q9Y6Q1 |
UCSC ID: | uc004epc.1 | OMIM ID: | 300146 |
Pubmed: | PMID9503024 PMID 9339374 | ||
CCDS IDs: | CCDSCCDS14555.1 |
Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large subunit possesses a cysteine protease domain, and both subunits possess calcium-binding domains. Calpains have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. The protein encoded by this gene is highly expressed in the placenta. Its C-terminal region lacks any homology to the calmodulin-like domain of other calpains. The protein lacks critical active site residues and thus is suggested to be proteolytically inactive. The protein may play a role in tumor formation by inhibiting apoptosis and promoting angiogenesis. [provided by RefSeq, Nov 2009].
Function: Microtubule-stabilizing protein that may be involved in the regulation of microtubule dynamics and cytoskeletal organization. May act as a regulator of RAC1 activity through interaction with ARHGEF2 to control lamellipodial formation and cell mobility. Does not seem to have protease activity as it has lost the active site residues (By similarity).
Products for CAPN6 gene
Catalog | Product Name | Application | Company |
GFS:E04116 | calpain 6; ELISA kit | ELISA | n/a |
GFS:A04116 | calpain 6; Anti | ANTIBODIES | n/a |
GFS:P04116 | calpain 6; Protien | Protien | n/a |