Symbol: Name: ID: |
CAPN10 calpain 10 GFS:4055 |
Gene name: | CAPN10 |
Chromosome: | 2q37.3 |
Previous Symbols: | |
Previous Names: | |
Aliases: | |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1344392 | Rat Genome Database ID: | RGD:69354 |
HGNC ID: | HGNC:1477 | RefSeq IDs: | NM_023083 |
Entrez Gene ID: | 11132 | Ensembl Gene ID: | ENSG00000142330 |
VEGA IDs: | OTTHUMG00000133358 | UniProt ID: | Q9HC96 |
UCSC ID: | uc002vzk.1 | OMIM ID: | 605286 |
Pubmed: | PMID11017071 PMID 11018080 | ||
CCDS IDs: | CCDSCCDS33420.1 CCDS CCDS42838.1 |
Calpain-10 is a protein that in humans is encoded by the CAPN10 gene.
Calpains represent a ubiquitous, well-conserved family of calcium-dependent cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large catalytic subunit has four domains: domain I, the N-terminal regulatory domain that is processed upon calpain activation; domain II, the protease domain; domain III, a linker domain of unknown function; and domain IV, the calmodulin-like calcium-binding domain. This gene encodes a large subunit. It is an atypical calpain in that it lacks the calmodulin-like calcium-binding domain and instead has a divergent C-terminal domain. It is similar in organization to calpains 5 and 6. This gene is associated with type 2 or non-insulin-dependent diabetes mellitus (NIDDM), and is located within the NIDDM1 region. Multiple alternative transcript variants have been described for this gene. [provided by RefSeq, Sep 2010].
Function: Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.
Products for CAPN10 gene
Catalog | Product Name | Application | Company |
GFS:E04055 | calpain 10; ELISA kit | ELISA | n/a |
GFS:A04055 | calpain 10; Anti | ANTIBODIES | n/a |
GFS:P04055 | calpain 10; Protien | Protien | n/a |