Symbol: Name: ID: |
UGT2A1 UDP glucuronosyltransferase 2 family, polypeptide A1, complex locus GFS:2331 |
Gene name: | UGT2A1 |
Chromosome: | 4q13 |
Previous Symbols: | |
Previous Names: | UDP glycosyltransferase 2 family, polypeptide A1, "UDP glucuronosyltransferase 2 family, polypeptide A1" |
Aliases: | |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:2149905 | Rat Genome Database ID: | RGD:69432 |
HGNC ID: | HGNC:12542 | RefSeq IDs: | NM_006798 |
Entrez Gene ID: | 10941 | Ensembl Gene ID: | ENSG00000173610 |
VEGA IDs: | OTTHUMG00000129398 | UniProt ID: | Q9Y4X1 |
UCSC ID: | uc003hem.3 | OMIM ID: | 604716 |
Pubmed: | PMID10359671 | ||
CCDS IDs: | CCDSCCDS3529.1 |
The olfactory neuroepithelium, which lines the posterior nasal cavity, is exposed to a wide range of odorants and airborne toxic compounds. Odorants, which are mostly small lipophilic molecules, enter the mucus flow and reach the odorant receptors on sensory neurons. Odorant sensing is generally a transient process, requiring an effective signal termination, which could be provided by biotransformation of the odorant in the epithelial supporting cells. Xenobiotic-metabolizing enzymes in the olfactory epithelium have been suggested to catalyze inactivation and facilitate elimination of odorants.[supplied by OMIM].
Function: UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Active on odorants and seems to be involved in olfaction; it could help clear lipophilic odorant molecules from the sensory epithelium.
Products for UGT2A1 gene
Catalog | Product Name | Application | Company |
GFS:E02331 | UDP glucuronosyltransferase 2 family, polypeptide A1, complex locus; ELISA kit | ELISA | n/a |
GFS:A02331 | UDP glucuronosyltransferase 2 family, polypeptide A1, complex locus; Anti | ANTIBODIES | n/a |
GFS:P02331 | UDP glucuronosyltransferase 2 family, polypeptide A1, complex locus; Protien | Protien | n/a |