Symbol: Name: ID: |
UGT1A4 UDP glucuronosyltransferase 1 family, polypeptide A4 GFS:2325 |
Gene name: | UGT1A4 |
Chromosome: | 2q37 |
Previous Symbols: | |
Previous Names: | UDP glycosyltransferase 1 family, polypeptide A4 |
Aliases: | HUG-BR2, UGT1D |
Name Aliases: | |
Locus Type: | complex locus constituent |
Mouse Genome Database ID: | Rat Genome Database ID: | ||
HGNC ID: | HGNC:12536 | RefSeq IDs: | NM_007120 |
Entrez Gene ID: | 54657 | Ensembl Gene ID: | ENSG00000244474 |
VEGA IDs: | OTTHUMG00000059119 | UniProt ID: | P22310 |
UCSC ID: | OMIM ID: | 606429 | |
Pubmed: | PMID9295054 PMID 1339448 | ||
CCDS IDs: | CCDSCCDS33405.1 |
UDP-glucuronosyltransferase 1-4 is an enzyme that in humans is encoded by the UGT1A4 gene.
This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. This enzyme has some glucuronidase activity towards bilirubin, although is is more active on amines, steroids, and sapogenins. (provided by RefSeq)
Function: UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform glucuronidates bilirubin IX-alpha to form both the IX-alpha-C8 and IX-alpha-C12 monoconjugates and diconjugate.
Products for UGT1A4 gene
Catalog | Product Name | Application | Company |
GFS:E02325 | UDP glucuronosyltransferase 1 family, polypeptide A4; ELISA kit | ELISA | n/a |
GFS:A02325 | UDP glucuronosyltransferase 1 family, polypeptide A4; Anti | ANTIBODIES | n/a |
GFS:P02325 | UDP glucuronosyltransferase 1 family, polypeptide A4; Protien | Protien | n/a |