Symbol: Name: ID: |
UGT1A1 UDP glucuronosyltransferase 1 family, polypeptide A1 GFS:2319 |
Gene name: | UGT1A1 |
Chromosome: | 2q37 |
Previous Symbols: | UGT1, GNT1 |
Previous Names: | UDP glycosyltransferase 1 family, polypeptide A1 |
Aliases: | UGT1A |
Name Aliases: | |
Locus Type: | complex locus constituent |
Mouse Genome Database ID: | MGI:98898 | Rat Genome Database ID: | RGD:3935 |
HGNC ID: | HGNC:12530 | RefSeq IDs: | NM_000463 |
Entrez Gene ID: | 54658 | Ensembl Gene ID: | ENSG00000241635 |
VEGA IDs: | OTTHUMG00000059117 | UniProt ID: | P22309 |
UCSC ID: | uc002vvb.2 | OMIM ID: | 191740 |
Pubmed: | PMID9295054 PMID 9535849 | ||
CCDS IDs: | CCDSCCDS2510.1 |
UDP-glucuronosyltransferase 1-1 also known as UGT-1A is an enzyme that in humans is encoded by the UGT1A1 gene.
This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The preferred substrate of this enzyme is bilirubin, although it also has moderate activity with simple phenols, flavones, and C18 steroids. Mutations in this gene result in Crigler-Najjar syndromes types I and II and in Gilbert syndrome. [provided by RefSeq]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Products for UGT1A1 gene
Catalog | Product Name | Application | Company |
GFS:E02319 | UDP glucuronosyltransferase 1 family, polypeptide A1; ELISA kit | ELISA | n/a |
GFS:A02319 | UDP glucuronosyltransferase 1 family, polypeptide A1; Anti | ANTIBODIES | n/a |
GFS:P02319 | UDP glucuronosyltransferase 1 family, polypeptide A1; Protien | Protien | n/a |