Transcription factor SOX-21 is a protein that in humans is encoded by the SOX21 gene.It is a member of the Sox gene family of transcription factors. SRY-related HMG-box (SOX) genes encode a family of DNA-binding proteins containing a 79-amino acid HMG (high mobility group) domain that shares at least 50% sequence identity with the DNA-binding HMG box of the SRY protein (MIM 480000). SOX proteins are divided into 6 subgroups based on sequence similarity within and outside of the HMG domain. For additional background information on SOX genes, see SOX1 (MIM 602148).[supplied by OMIM].
Function: May play a role as an activator of transcription of OPRM1 (By similarity).