Symbol: Name: ID: |
FBXL5 F-box and leucine-rich repeat protein 5 GFS:3146 |
Gene name: | FBXL5 |
Chromosome: | 4p15.33 |
Previous Symbols: | |
Previous Names: | |
Aliases: | FBL4, FBL5, FLR1 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:2152883 | Rat Genome Database ID: | RGD:1306887 |
HGNC ID: | HGNC:13602 | RefSeq IDs: | NM_012161 |
Entrez Gene ID: | 26234 | Ensembl Gene ID: | ENSG00000118564 |
VEGA IDs: | OTTHUMG00000097097 | UniProt ID: | Q9UKA1 |
UCSC ID: | uc003goc.1 | OMIM ID: | 605655 |
Pubmed: | PMID10531035 | ||
CCDS IDs: | CCDSCCDS3415.1 |
F-box/LRR-repeat protein 5 is a protein that in humans is encoded by the FBXL5 gene.
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains several tandem leucine-rich repeats. Alternatively spliced transcript variants have been described for this locus. [provided by RefSeq, Aug 2010].
Function: Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in iron homeostasis by promoting the ubiquitination and subsequent degradation of IREB2/IRP2. Upon high iron and oxygen level, it specifically recognizes and binds IREB2/IRP2, promoting its ubiquitination and degradation by the proteasome. Promotes ubiquitination and subsequent degradation of DCTN1/p150-glued.
Products for FBXL5 gene
Catalog | Product Name | Application | Company |
GFS:E03146 | F-box and leucine-rich repeat protein 5; ELISA kit | ELISA | n/a |
GFS:A03146 | F-box and leucine-rich repeat protein 5; Anti | ANTIBODIES | n/a |
GFS:P03146 | F-box and leucine-rich repeat protein 5; Protien | Protien | n/a |