Symbol: Name: ID: |
FBXL2 F-box and leucine-rich repeat protein 2 GFS:3141 |
Gene name: | FBXL2 |
Chromosome: | 3p22.3 |
Previous Symbols: | |
Previous Names: | |
Aliases: | FBL2, FBL3 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1919429 | Rat Genome Database ID: | RGD:1562243 |
HGNC ID: | HGNC:13598 | RefSeq IDs: | NM_001171713 |
Entrez Gene ID: | 25827 | Ensembl Gene ID: | ENSG00000153558 |
VEGA IDs: | OTTHUMG00000130745 | UniProt ID: | Q9UKC9 |
UCSC ID: | uc003cfp.2 | OMIM ID: | 605652 |
Pubmed: | PMID10508920 PMID 10531035 | ||
CCDS IDs: | CCDSCCDS2658.1 |
F-box/LRR-repeat protein 2 is a protein that in humans is encoded by the FBXL2 gene.
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains 12 tandem leucine-rich repeats. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2010].
Function: Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. Binds to hepatitis C virus non-structural protein 5A (NS5A) in a reaction crucial for hepatitis C virus RNA replication.
Products for FBXL2 gene
Catalog | Product Name | Application | Company |
GFS:E03141 | F-box and leucine-rich repeat protein 2; ELISA kit | ELISA | n/a |
GFS:A03141 | F-box and leucine-rich repeat protein 2; Anti | ANTIBODIES | n/a |
GFS:P03141 | F-box and leucine-rich repeat protein 2; Protien | Protien | n/a |