Symbol: Name: ID: |
FBXL21 F-box and leucine-rich repeat protein 21 (gene/pseudogene) GFS:3144 |
Gene name: | FBXL21 |
Chromosome: | 5q31 |
Previous Symbols: | FBXL3B, FBXL3P |
Previous Names: | F-box and leucine-rich repeat protein 3 pseudogene, "F-box and leucine-rich repeat protein 21" |
Aliases: | FBL3B, Fbl21 |
Name Aliases: | F-box and leucine-rich repeat protein 3B |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:2442921 | Rat Genome Database ID: | |
HGNC ID: | HGNC:13600 | RefSeq IDs: | NM_012159 |
Entrez Gene ID: | 26223 | Ensembl Gene ID: | ENSG00000164616 |
VEGA IDs: | OTTHUMG00000155971 | UniProt ID: | Q9UKT6 |
UCSC ID: | uc010jec.1 | OMIM ID: | 609087 |
Pubmed: | PMID10531035 | ||
CCDS IDs: |
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains 6 tandem leucine-rich repeats. The amino acid sequence of this protein is highly similar to that of f-box and leucine-rich repeat protein 3A. Comparisons of this gene to orthologous sequences suggest that it may be a pseudogene, and may no longer express a functional protein.[provided by RefSeq, Aug 2009]. Sequence Note: This RefSeq record retains a mismatch versus the reference genome sequence and available transcript data; translation of the genomic sequence results in a nonsense codon and truncation of the predicted protein. In addition, the transcript represents a splice pattern that uses AT-AG splice sites for the last intron, but it is not known if these splice site are functional in vivo.
Function: Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex involved in circadian pacemaker function. The SCF(FBXL21) complex acts by mediating ubiquitination and subsequent degradation of CRY1. Probable clock-controlled protein that plays a specific role in suprachiasmatic nucleus, SCN and pacemaker function (By similarity.
Products for FBXL21 gene
Catalog | Product Name | Application | Company |
GFS:E03144 | F-box and leucine-rich repeat protein 21 (gene/pseudogene); ELISA kit | ELISA | n/a |
GFS:A03144 | F-box and leucine-rich repeat protein 21 (gene/pseudogene); Anti | ANTIBODIES | n/a |
GFS:P03144 | F-box and leucine-rich repeat protein 21 (gene/pseudogene); Protien | Protien | n/a |