Symbol: Name: ID: |
FBXL3 F-box and leucine-rich repeat protein 3 GFS:3142 |
Gene name: | FBXL3 |
Chromosome: | 13q22 |
Previous Symbols: | FBXL3A |
Previous Names: | F-box and leucine-rich repeat protein 3A |
Aliases: | FBL3, FBL3A |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1354702 | Rat Genome Database ID: | RGD:1305660 |
HGNC ID: | HGNC:13599 | RefSeq IDs: | NM_012158 |
Entrez Gene ID: | 26224 | Ensembl Gene ID: | ENSG00000005812 |
VEGA IDs: | OTTHUMG00000017099 | UniProt ID: | Q9UKT7 |
UCSC ID: | uc001vkd.2 | OMIM ID: | 605653 |
Pubmed: | PMID10531035 PMID 10828603 | ||
CCDS IDs: | CCDSCCDS9457.1 |
F-box/LRR-repeat protein 3 is a protein that in humans is encoded by the FBXL3 gene.
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains several tandem leucine-rich repeats and is localized in the nucleus. [provided by RefSeq, Jul 2008].
Function: Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex involved in circadian clock function. The SCF(FBXL3) complex acts by mediating ubiquitination and subsequent degradation of CRY1 and CRY2. Recruiter of target protein that may recognize and bind to some phosphorylated proteins and promotes their ubiquitination and degradation.
Products for FBXL3 gene
Catalog | Product Name | Application | Company |
GFS:E03142 | F-box and leucine-rich repeat protein 3; ELISA kit | ELISA | n/a |
GFS:A03142 | F-box and leucine-rich repeat protein 3; Anti | ANTIBODIES | n/a |
GFS:P03142 | F-box and leucine-rich repeat protein 3; Protien | Protien | n/a |