Symbol: Name: ID: |
BCL6 B-cell CLL/lymphoma 6 GFS:12 |
Gene name: | BCL6 |
Chromosome: | 3q27 |
Previous Symbols: | ZNF51 |
Previous Names: | zinc finger protein 51 |
Aliases: | ZBTB27, LAZ3, BCL5, BCL6A |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:107187 | Rat Genome Database ID: | RGD:1309345 |
HGNC ID: | HGNC:1001 | RefSeq IDs: | NM_001130845 |
Entrez Gene ID: | 604 | Ensembl Gene ID: | ENSG00000113916 |
VEGA IDs: | OTTHUMG00000156441 | UniProt ID: | P41182 |
UCSC ID: | uc003frq.1 | OMIM ID: | 109565 |
Pubmed: | |||
CCDS IDs: | CCDSCCDS3289.1 CCDS CCDS46975.1 |
B-cell CLL/lymphoma 6 by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of START-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene.
BCL6 functions as a transcriptional repressor and is necessary for germinal center formation. Approximately 40% of diffuse large cell lymphomas and 5 to 10% of follicular lymphomas are associated with chromosomal translocations that deregulate expression of BCL6 by juxtaposing heterologous promoters to the BCL6 coding domain
Products for BCL6 gene
Catalog | Product Name | Application | Company |
GFS:E00012 | B-cell CLL/lymphoma 6; ELISA kit | ELISA | n/a |
GFS:A00012 | B-cell CLL/lymphoma 6; Anti | ANTIBODIES | n/a |
GFS:P00012 | B-cell CLL/lymphoma 6; Protien | Protien | n/a |