Symbol: Name: ID: |
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein) GFS:2877 |
Gene name: | BCL11A |
Chromosome: | 2p16.1 |
Previous Symbols: | EVI9 |
Previous Names: | ecotropic viral integration site 9 |
Aliases: | BCL11A-XL, BCL11A-L, BCL11A-S, CTIP1, HBFQTL5, ZNF856 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:106190 | Rat Genome Database ID: | RGD:1309923 |
HGNC ID: | HGNC:13221 | RefSeq IDs: | NM_018014 |
Entrez Gene ID: | 53335 | Ensembl Gene ID: | ENSG00000119866 |
VEGA IDs: | OTTHUMG00000129420 | UniProt ID: | Q9H165 |
UCSC ID: | uc002sae.1 | OMIM ID: | 606557 |
Pubmed: | PMID11719382 PMID 18245381 | ||
CCDS IDs: | CCDSCCDS1861.1 CCDS CCDS1862.1 CCDS CCDS46295.1 |
B-cell lymphoma/leukemia 11A is a protein that in humans is encoded by the BCL11A gene.
This gene encodes a C2H2 type zinc-finger protein by its similarity to the mouse Bcl11a/Evi9 protein. The corresponding mouse gene is a common site of retroviral integration in myeloid leukemia, and may function as a leukemia disease gene, in part, through its interaction with BCL6. During hematopoietic cell differentiation, this gene is down-regulated. It is possibly involved in lymphoma pathogenesis since translocations associated with B-cell malignancies also deregulates its expression. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq].
Function: Functions as a myeloid and B-cell proto-oncogene. May play important roles in leukemogenesis and hematopoiesis. An essential factor in lymphopoiesis, is required for B-cell formation in fetal liver. May function as a modulator of the transcriptional repression activity of ARP1 (By similarity).
Products for BCL11A gene
Catalog | Product Name | Application | Company |
GFS:E02877 | B-cell CLL/lymphoma 11A (zinc finger protein); ELISA kit | ELISA | n/a |
GFS:A02877 | B-cell CLL/lymphoma 11A (zinc finger protein); Anti | ANTIBODIES | n/a |
GFS:P02877 | B-cell CLL/lymphoma 11A (zinc finger protein); Protien | Protien | n/a |