Symbol: Name: ID: |
BCL5 B-cell CLL/lymphoma 5 GFS:2 |
Gene name: | BCL5 |
Chromosome: | 17q22 |
Previous Symbols: | |
Previous Names: | |
Aliases: | |
Name Aliases: | |
Locus Type: | phenotype only |
Mouse Genome Database ID: | Rat Genome Database ID: | ||
HGNC ID: | HGNC:1000 | RefSeq IDs: | |
Entrez Gene ID: | 603 | Ensembl Gene ID: | |
VEGA IDs: | UniProt ID: | ||
UCSC ID: | OMIM ID: | 151441 | |
Pubmed: | PMID2682663 PMID 8400234 | ||
CCDS IDs: |
The BCL5 locus to 17q22 and found that it was transcribed as a message of 1.7 kb in many hematopoietic cell lines representing all hematopoietic lineages. In the patient's leukemia cells, the truncated MYC gene was highly expressed under the influence of BCL5 regulatory elements, leading to an aggressive B-cell leukemia that presumably had been derived from an indolent lymphoma carrying a rearranged BCL2 gene. who referred to the locus as 'BCL-3,' provided a molecular analysis of this locus, called here BCL5, at 17q22. In 264 B-cell malignancies, Southern blot analysis showed rearrangements of the locus in only 4 cases. All were follicular lymphomas and all had BCL2 rearrangements consistent with their follicular center cell origin. concluded that although the preferential involvement of BCL5 alterations in a small subset of follicular lymphomas that transform suggests a possible link with progression, further studies are needed to ensure that these alterations are biologically relevant and not simply a manifestation of genomic instability.
Products for BCL5 gene
Catalog | Product Name | Application | Company |
GFS:E00002 | B-cell CLL/lymphoma 5; ELISA kit | ELISA | n/a |
GFS:A00002 | B-cell CLL/lymphoma 5; Anti | ANTIBODIES | n/a |
GFS:P00002 | B-cell CLL/lymphoma 5; Protien | Protien | n/a |