Symbol: Name: ID: |
ADAM10 ADAM metallopeptidase domain 10 GFS:7623 |
Gene name: | ADAM10 |
Chromosome: | 15q2 |
Previous Symbols: | |
Previous Names: | a disintegrin and metalloproteinase domain 10 |
Aliases: | kuz, MADM, HsT18717, CD156c |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:109548 | Rat Genome Database ID: | RGD:2032 |
HGNC ID: | HGNC:188 | RefSeq IDs: | NM_001110 |
Entrez Gene ID: | 102 | Ensembl Gene ID: | ENSG00000137845 |
VEGA IDs: | OTTHUMG00000132633 | UniProt ID: | O14672 |
UCSC ID: | uc002afd.1 | OMIM ID: | 602192 |
Pubmed: | PMID9344679 PMID 9441766 | ||
CCDS IDs: | CCDSCCDS10167.1 |
Disintegrin and metalloproteinase domain-containing protein 10, also known as ADAM10 or CDw156 or CD156c is a protein that in humans is encoded by the ADAM10 gene.
Members of the ADAM family are cell surface proteins with a unique structure possessing both potential adhesion and protease domains. This gene encodes and ADAM family member that cleaves many proteins including TNF-alpha and E-cadherin. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Function: Cleaves the membrane-bound precursor of TNF-alpha at '76-Ala- -Val-77' to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP). Contributes to the normal cleavage of the cellular prion protein. Involved in the cleavage of the adhesion molecule L1 at the cell surface and in released membrane vesicles, suggesting a vesicle-based protease activity. Controls also the proteolytic processing of Notch and mediates lateral inhibition during neurogenesis (By similarity).
Products for ADAM10 gene
Catalog | Product Name | Application | Company |
GFS:E07623 | ADAM metallopeptidase domain 10; ELISA kit | ELISA | n/a |
GFS:A07623 | ADAM metallopeptidase domain 10; Anti | ANTIBODIES | n/a |
GFS:P07623 | ADAM metallopeptidase domain 10; Protien | Protien | n/a |