Symbol: Name: ID: |
ADAMTS13 ADAM metallopeptidase with thrombospondin type 1 motif, 13 GFS:3189 |
Gene name: | ADAMTS13 |
Chromosome: | 9q34 |
Previous Symbols: | C9orf8 |
Previous Names: | a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 13 |
Aliases: | VWFCP, TTP, vWF-CP, FLJ42993, MGC118899, MGC118900, DKFZp434C2322 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:2685556 | Rat Genome Database ID: | RGD:1311594 |
HGNC ID: | HGNC:1366 | RefSeq IDs: | NM_139025 |
Entrez Gene ID: | 11093 | Ensembl Gene ID: | ENSG00000160323 |
VEGA IDs: | OTTHUMG00000020876 | UniProt ID: | Q76LX8 |
UCSC ID: | uc004cdv.3 | OMIM ID: | 604134 |
Pubmed: | PMID11557746 PMID 11535495 | ||
CCDS IDs: | CCDSCCDS6970.1 CCDS CCDS6971.1 CCDS CCDS6972.1 |
ADAMTS13 (a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13)—also known as von Willebrand factor-cleaving protease (VWFCP)—is a zinc-containing metalloprotease enzyme that cleaves von Willebrand factor (vWf), a large protein involved in blood clotting. It is secreted in blood and degrades large vWf multimers, decreasing their activity.
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene is the von Willebrand Factor (vWF)-cleaving protease, which is responsible for cleaving at the site of Tyr842-Met843 of the vWF molecule. A deficiency of this enzyme is associated with thrombotic thrombocytopenic purpura. Alternative splicing of this gene generates multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2008].
Function: Cleaves the vWF multimers in plasma into smaller forms.
Products for ADAMTS13 gene
Catalog | Product Name | Application | Company |
GFS:E03189 | ADAM metallopeptidase with thrombospondin type 1 motif, 13; ELISA kit | ELISA | n/a |
GFS:A03189 | ADAM metallopeptidase with thrombospondin type 1 motif, 13; Anti | ANTIBODIES | n/a |
GFS:P03189 | ADAM metallopeptidase with thrombospondin type 1 motif, 13; Protien | Protien | n/a |