Symbol: Name: ID: |
ADAMTS14 ADAM metallopeptidase with thrombospondin type 1 motif, 14 GFS:4185 |
Gene name: | ADAMTS14 |
Chromosome: | 10q21 |
Previous Symbols: | |
Previous Names: | a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 14 |
Aliases: | |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:2179942 | Rat Genome Database ID: | RGD:1308899 |
HGNC ID: | HGNC:14899 | RefSeq IDs: | NM_080722 |
Entrez Gene ID: | 140766 | Ensembl Gene ID: | ENSG00000138316 |
VEGA IDs: | OTTHUMG00000018414 | UniProt ID: | Q8WXS8 |
UCSC ID: | uc001jrg.2 | OMIM ID: | 607506 |
Pubmed: | PMID11779638 | ||
CCDS IDs: | CCDSCCDS7306.1 CCDS CCDS7307.1 |
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. This gene is highly similar to two family members, ADAMTS2 and ADAMTS3, in its sequence and gene structure, and the encoded protein shares the aminoprocollagen peptidase activity with the protein products encoded by ADAMTS2 and ADAMTS3. Various transcript variants of this gene have been identified. They result from the use of two different promoters and transcription initiation sites as well as alternative splicing sites. The full length nature of some transcripts has not been defined. [provided by RefSeq, Jul 2008].
Function: Has a aminoprocollagen type I activity processing activity in the absence of ADAMTS2. Seems to be synthesized as a latent enzyme that requires activation to display aminoprocollagen peptidase activity.
Products for ADAMTS14 gene
Catalog | Product Name | Application | Company |
GFS:E04185 | ADAM metallopeptidase with thrombospondin type 1 motif, 14; ELISA kit | ELISA | n/a |
GFS:A04185 | ADAM metallopeptidase with thrombospondin type 1 motif, 14; Anti | ANTIBODIES | n/a |
GFS:P04185 | ADAM metallopeptidase with thrombospondin type 1 motif, 14; Protien | Protien | n/a |