Symbol: Name: ID: |
ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif, 12 GFS:3907 |
Gene name: | ADAMTS12 |
Chromosome: | 5q35 |
Previous Symbols: | |
Previous Names: | a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 12 |
Aliases: | |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:2146046 | Rat Genome Database ID: | RGD:1307323 |
HGNC ID: | HGNC:14605 | RefSeq IDs: | NM_030955 |
Entrez Gene ID: | 81792 | Ensembl Gene ID: | ENSG00000151388 |
VEGA IDs: | UniProt ID: | P58397 | |
UCSC ID: | uc003jia.1 | OMIM ID: | 606184 |
Pubmed: | PMID11279086 | ||
CCDS IDs: | CCDSCCDS34140.1 |
A disintegrin and metalloproteinase with thrombospondin motifs 12 is an enzyme that in humans is encoded by the ADAMTS12 gene.
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS-1) motif. Individual members of this family differ in the number of C-terminal TS-1 motifs, and some have unique C-terminal domains. The enzyme encoded by this gene contains eight TS-1 motifs. It may play roles in pulmonary cells during fetal development or in tumor processes through its proteolytic activity or as a molecule potentially involved in regulation of cell adhesion. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Function: Metalloprotease that may plays a role in the degradation of COMP. Cleaves also alpha-2 macroglobulin and aggregan. Has anti-tumorigenesis properties.
Products for ADAMTS12 gene
Catalog | Product Name | Application | Company |
GFS:E03907 | ADAM metallopeptidase with thrombospondin type 1 motif, 12; ELISA kit | ELISA | n/a |
GFS:A03907 | ADAM metallopeptidase with thrombospondin type 1 motif, 12; Anti | ANTIBODIES | n/a |
GFS:P03907 | ADAM metallopeptidase with thrombospondin type 1 motif, 12; Protien | Protien | n/a |