Symbol: Name: ID: |
ZFP91 zinc finger protein 91 homolog (mouse) GFS:4265 |
Gene name: | ZFP91 |
Chromosome: | 11q12 |
Previous Symbols: | |
Previous Names: | zinc finger protein homologous to Zfp91 in mouse |
Aliases: | PZF, ZNF757 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:104854 | Rat Genome Database ID: | RGD:628736 |
HGNC ID: | HGNC:14983 | RefSeq IDs: | NM_001197051 |
Entrez Gene ID: | 80829 | Ensembl Gene ID: | ENSG00000186660 |
VEGA IDs: | OTTHUMG00000137391 | UniProt ID: | Q96JP5 |
UCSC ID: | uc001nmx.3 | OMIM ID: | |
Pubmed: | PMID12738986 | ||
CCDS IDs: | CCDSCCDS31553.1 |
Zinc finger protein 91 homolog is a protein that in humans is encoded by the ZFP91 gene.
The protein encoded by this gene is a member of the zinc finger family of proteins. The gene product contains C2H2-type domains, which are the classical zinc finger domains found in numerous nucleic acid-binding proteins. This protein functions as a regulator of the non-canonical NF-kappaB pathway in lymphotoxin-beta receptor signaling. Alternative splicing results in multiple transcript variants. A read-through transcript variant composed of ZFP91 and the downstream CNTF gene sequence has been identified, but it is thought to be non-coding. Read-through transcription of ZFP91 and CNTF has also been observed in mouse. A ZFP91-related pseudogene has also been identified on chromosome 2. [provided by RefSeq, Oct 2010].
Function: Atypical E3 ubiquitin-protein ligase that mediates 'Lys-63'-linked ubiquitination of MAP3K14/NIK, leading to stabilize and activate MAP3K14/NIK. It thereby acts as an activator of the non-canonical NF-kappa-B2/NFKB2 pathway. May also play an important role in cell proliferation and/or anti-apoptosis.
Products for ZFP91 gene
Catalog | Product Name | Application | Company |
GFS:E04265 | zinc finger protein 91 homolog (mouse); ELISA kit | ELISA | n/a |
GFS:A04265 | zinc finger protein 91 homolog (mouse); Anti | ANTIBODIES | n/a |
GFS:P04265 | zinc finger protein 91 homolog (mouse); Protien | Protien | n/a |