Symbol: Name: ID: |
ZFPM2 zinc finger protein, multitype 2 GFS:5797 |
Gene name: | ZFPM2 |
Chromosome: | 8q23 |
Previous Symbols: | |
Previous Names: | |
Aliases: | FOG2, hFOG-2, ZNF89B |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1334444 | Rat Genome Database ID: | RGD:1306021 |
HGNC ID: | HGNC:16700 | RefSeq IDs: | NM_012082 |
Entrez Gene ID: | 23414 | Ensembl Gene ID: | ENSG00000169946 |
VEGA IDs: | UniProt ID: | Q8WW38 | |
UCSC ID: | uc003ymd.2 | OMIM ID: | 603693 |
Pubmed: | PMID9927675 PMID 10438528 | ||
CCDS IDs: | CCDSCCDS47908.1 |
Zinc finger protein ZFPM2 is a protein that in humans is encoded by the ZFPM2 gene.
The zinc finger protein encoded by this gene is a widely expressed member of the FOG family of transcription factors. The family members modulate the activity of GATA family proteins, which are important regulators of hematopoiesis and cardiogenesis in mammals. It has been demonstrated that the protein can both activate and down-regulate expression of GATA-target genes, suggesting different modulation in different promoter contexts. A related mRNA suggests an alternatively spliced product but this information is not yet fully supported by the sequence. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Function: Transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA4, GATA5 and GATA6. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. Also required in gonadal differentiation, possibly be regulating expression of SRY. Probably acts a corepressor of NR2F2 (By similarity).
Products for ZFPM2 gene
Catalog | Product Name | Application | Company |
GFS:E05797 | zinc finger protein, multitype 2; ELISA kit | ELISA | n/a |
GFS:A05797 | zinc finger protein, multitype 2; Anti | ANTIBODIES | n/a |
GFS:P05797 | zinc finger protein, multitype 2; Protien | Protien | n/a |