Symbol: Name: ID: |
ZBTB7B zinc finger and BTB domain containing 7B GFS:7512 |
Gene name: | ZBTB7B |
Chromosome: | 1q21.2 |
Previous Symbols: | ZFP67 |
Previous Names: | zinc finger protein 67 homolog (mouse) |
Aliases: | ZBTB15, c-Krox, hcKrox, ZNF857B |
Name Aliases: | zinc finger and BTB domain containing 15 |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:102755 | Rat Genome Database ID: | RGD:1305963 |
HGNC ID: | HGNC:18668 | RefSeq IDs: | NM_015872 |
Entrez Gene ID: | 51043 | Ensembl Gene ID: | ENSG00000160685 |
VEGA IDs: | OTTHUMG00000037414 | UniProt ID: | O15156 |
UCSC ID: | uc001fgk.3 | OMIM ID: | 607646 |
Pubmed: | PMID9370309 PMID 7937772 | ||
CCDS IDs: | CCDSCCDS1081.1 |
Zinc finger and BTB domain-containing protein 7B is a protein that in humans is encoded by the ZBTB7B gene.
This gene encodes a zinc finger-containing transcription factor that acts as a key regulator of lineage commitment of immature T-cell precursors. It is necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment. It also functions as a transcriptional repressor of type I collagen genes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011].
Function: Transcription regulator that acts as a key regulator of lineage commitment of immature T-cell precursors. Necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment. Development of immature T-cell precursors (thymocytes) to either the CD4 helper or CD8 killer T-cell lineages correlates precisely with their T-cell receptor specificity for major histocompatibility complex class II or class I molecules, respectively. Transcriptional repressor of the collagen COL1A1 and COL1A2 genes. May also function as a repressor of fibronectin and possibly other extracellular matrix genes (By similarity).
Products for ZBTB7B gene
Catalog | Product Name | Application | Company |
GFS:E07512 | zinc finger and BTB domain containing 7B; ELISA kit | ELISA | n/a |
GFS:A07512 | zinc finger and BTB domain containing 7B; Anti | ANTIBODIES | n/a |
GFS:P07512 | zinc finger and BTB domain containing 7B; Protien | Protien | n/a |