Symbol: Name: ID: |
ZBTB33 zinc finger and BTB domain containing 33 GFS:5779 |
Gene name: | ZBTB33 |
Chromosome: | Xq23 |
Previous Symbols: | |
Previous Names: | |
Aliases: | ZNF-kaiso, kaiso, WUGSC:H_DJ525N14.1, KAISO, ZNF348 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1927290 | Rat Genome Database ID: | RGD:1566309 |
HGNC ID: | HGNC:16682 | RefSeq IDs: | NM_001184742 |
Entrez Gene ID: | 10009 | Ensembl Gene ID: | ENSG00000177485 |
VEGA IDs: | OTTHUMG00000022296 | UniProt ID: | Q86T24 |
UCSC ID: | uc004esn.1 | OMIM ID: | 300329 |
Pubmed: | |||
CCDS IDs: | CCDSCCDS14596.1 |
Transcriptional regulator Kaiso is a protein that in humans is encoded by the ZBTB33 gene.
This gene encodes a transcriptional regulator with bimodal DNA-binding specificity, which binds to methylated CGCG and also to the non-methylated consensus KAISO-binding site TCCTGCNA. The protein contains an N-terminal POZ/BTB domain and 3 C-terminal zinc finger motifs. It recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. It may contribute to the repression of target genes of the Wnt signaling pathway, and may also activate transcription of a subset of target genes by the recruitment of catenin delta-2 (CTNND2). Its interaction with catenin delta-1 (CTNND1) inhibits binding to both methylated and non-methylated DNA. It also interacts directly with the nuclear import receptor Importin-α2 (also known as karyopherin alpha2 or RAG cohort 1), which may mediate nuclear import of this protein. Alternatively spliced transcript variants encoding the same protein have been identified.[provided by RefSeq, May 2010].
Function: Transcriptional regulator with bimodal DNA-binding specificity. Binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' and also binds to the non-methylated consensus sequence 5'-CTGCNA-3'. Recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. May contribute to the repression of target genes of the Wnt signaling pathway. May also activate transcription of a subset of target genes by the recruitment of CTNND2.
Products for ZBTB33 gene
Catalog | Product Name | Application | Company |
GFS:E05779 | zinc finger and BTB domain containing 33; ELISA kit | ELISA | n/a |
GFS:A05779 | zinc finger and BTB domain containing 33; Anti | ANTIBODIES | n/a |
GFS:P05779 | zinc finger and BTB domain containing 33; Protien | Protien | n/a |