Symbol: Name: ID: |
WNT1 wingless-type MMTV integration site family, member 1 GFS:2533 |
Gene name: | WNT1 |
Chromosome: | 12q13 |
Previous Symbols: | INT1 |
Previous Names: | |
Aliases: | |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:98953 | Rat Genome Database ID: | RGD:1597195 |
HGNC ID: | HGNC:12774 | RefSeq IDs: | NM_005430 |
Entrez Gene ID: | 7471 | Ensembl Gene ID: | ENSG00000125084 |
VEGA IDs: | UniProt ID: | P04628 | |
UCSC ID: | uc001rsu.2 | OMIM ID: | 164820 |
Pubmed: | PMID2998762 PMID 3281802 | ||
CCDS IDs: | CCDSCCDS8776.1 |
Proto-oncogene protein Wnt-1 is a protein that in humans is encoded by the WNT1 gene.
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is very conserved in evolution, and the protein encoded by this gene is known to be 98% identical to the mouse Wnt1 protein at the amino acid level. The studies in mouse indicate that the Wnt1 protein functions in the induction of the mesencephalon and cerebellum. This gene was originally considered as a candidate gene for Joubert syndrome, an autosomal recessive disorder with cerebellar hypoplasia as a leading feature. However, further studies suggested that the gene mutations might not have a significant role in Joubert syndrome. This gene is clustered with another family member, WNT10B, in the chromosome 12q13 region. [provided by RefSeq]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments and orthologous data. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Products for WNT1 gene
Catalog | Product Name | Application | Company |
GFS:E02533 | wingless-type MMTV integration site family, member 1; ELISA kit | ELISA | n/a |
GFS:A02533 | wingless-type MMTV integration site family, member 1; Anti | ANTIBODIES | n/a |
GFS:P02533 | wingless-type MMTV integration site family, member 1; Protien | Protien | n/a |