Symbol: Name: ID: |
UBA7 ubiquitin-like modifier activating enzyme 7 GFS:2264 |
Gene name: | UBA7 |
Chromosome: | 3p21 |
Previous Symbols: | UBE1L |
Previous Names: | ubiquitin-activating enzyme E1-like |
Aliases: | D8, UBE2, UBA1B |
Name Aliases: | UBA1, ubiquitin-activating enzyme E1 homolog B (yeast), |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1349462 | Rat Genome Database ID: | RGD:1308323 |
HGNC ID: | HGNC:12471 | RefSeq IDs: | NM_003335 |
Entrez Gene ID: | 7318 | Ensembl Gene ID: | ENSG00000182179 |
VEGA IDs: | OTTHUMG00000158267 | UniProt ID: | P41226 |
UCSC ID: | uc003cxr.2 | OMIM ID: | 191325 |
Pubmed: | PMID8327486 | ||
CCDS IDs: | CCDSCCDS2805.1 |
Ubiquitin-like modifier-activating enzyme 7 is a protein that in humans is encoded by the UBA7 gene.
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme is a retinoid target that triggers promyelocytic leukemia (PML)/retinoic acid receptor alpha (RARalpha) degradation and apoptosis in acute promyelocytic leukemia, where it is involved in the conjugation of the ubiquitin-like interferon-stimulated gene 15 protein. [provided by RefSeq]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Function: Activates ubiquitin by first adenylating with ATP its C-terminal glycine residue and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding an ubiquitin-E1 thioester and free AMP.
Products for UBA7 gene
Catalog | Product Name | Application | Company |
GFS:E02264 | ubiquitin-like modifier activating enzyme 7; ELISA kit | ELISA | n/a |
GFS:A02264 | ubiquitin-like modifier activating enzyme 7; Anti | ANTIBODIES | n/a |
GFS:P02264 | ubiquitin-like modifier activating enzyme 7; Protien | Protien | n/a |