Symbol: Name: ID: |
UBA1 ubiquitin-like modifier activating enzyme 1 GFS:2261 |
Gene name: | UBA1 |
Chromosome: | Xp11.23 |
Previous Symbols: | A1S9T, GXP1, UBE1 |
Previous Names: | ubiquitin-activating enzyme E1 (A1S9T and BN75 temperature sensitivity complementing), "ubiquitin-activating enzyme E1" |
Aliases: | UBE1X, POC20 |
Name Aliases: | UBA1, ubiquitin-activating enzyme E1 homolog (yeast), |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:98890 | Rat Genome Database ID: | RGD:1359327 |
HGNC ID: | HGNC:12469 | RefSeq IDs: | NM_003334 |
Entrez Gene ID: | 7317 | Ensembl Gene ID: | ENSG00000130985 |
VEGA IDs: | OTTHUMG00000021436 | UniProt ID: | P22314 |
UCSC ID: | uc004dhj.3 | OMIM ID: | 314370 |
Pubmed: | PMID1845793 | ||
CCDS IDs: | CCDSCCDS14275.1 |
The protein encoded by this gene catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation. This gene complements an X-linked mouse temperature-sensitive defect in DNA synthesis, and thus may function in DNA repair. It is part of a gene cluster on chromosome Xp11.23. Alternatively spliced transcript variants that encode the same protein have been described. [provided by RefSeq].
Function: Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding an ubiquitin-E1 thioester and free AMP.
Products for UBA1 gene
Catalog | Product Name | Application | Company |
GFS:E02261 | ubiquitin-like modifier activating enzyme 1; ELISA kit | ELISA | n/a |
GFS:A02261 | ubiquitin-like modifier activating enzyme 1; Anti | ANTIBODIES | n/a |
GFS:P02261 | ubiquitin-like modifier activating enzyme 1; Protien | Protien | n/a |