Symbol: Name: ID: |
UBA3 ubiquitin-like modifier activating enzyme 3 GFS:2263 |
Gene name: | UBA3 |
Chromosome: | 3p24.3-p13 |
Previous Symbols: | UBE1C |
Previous Names: | ubiquitin-activating enzyme E1C (homologous to yeast UBA3), "ubiquitin-activating enzyme E1C (UBA3 homolog, yeast)" |
Aliases: | hUba3 |
Name Aliases: | UBA3, ubiquitin-activating enzyme E1 homolog (yeast) |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1341217 | Rat Genome Database ID: | RGD:621084 |
HGNC ID: | HGNC:12470 | RefSeq IDs: | NM_003968 |
Entrez Gene ID: | 9039 | Ensembl Gene ID: | ENSG00000144744 |
VEGA IDs: | OTTHUMG00000154325 | UniProt ID: | Q8TBC4 |
UCSC ID: | uc003dno.2 | OMIM ID: | 603172 |
Pubmed: | PMID9694792 | ||
CCDS IDs: | CCDSCCDS2909.1 CCDS CCDS2910.1 |
NEDD8-activating enzyme E1 catalytic subunit is a protein that in humans is encoded by the UBA3 gene.
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme associates with AppBp1, an amyloid beta precursor protein binding protein, to form a heterodimer, and then the enzyme complex activates NEDD8, a ubiquitin-like protein, which regulates cell division, signaling and embryogenesis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq].
Function: Catalytic subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Down-regulates steroid receptor activity. Necessary for cell cycle progression.
Products for UBA3 gene
Catalog | Product Name | Application | Company |
GFS:E02263 | ubiquitin-like modifier activating enzyme 3; ELISA kit | ELISA | n/a |
GFS:A02263 | ubiquitin-like modifier activating enzyme 3; Anti | ANTIBODIES | n/a |
GFS:P02263 | ubiquitin-like modifier activating enzyme 3; Protien | Protien | n/a |