Symbol: Name: ID: |
ST5 suppression of tumorigenicity 5 GFS:1240 |
Gene name: | ST5 |
Chromosome: | 11p15 |
Previous Symbols: | |
Previous Names: | |
Aliases: | HTS1, DENND2B, p126 |
Name Aliases: | DENN/MADD domain containing 2B |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:108517 | Rat Genome Database ID: | RGD:1308995 |
HGNC ID: | HGNC:11350 | RefSeq IDs: | NM_005418 |
Entrez Gene ID: | 6764 | Ensembl Gene ID: | ENSG00000166444 |
VEGA IDs: | UniProt ID: | P78524 | |
UCSC ID: | uc001mgt.2 | OMIM ID: | 140750 |
Pubmed: | PMID1390339 | ||
CCDS IDs: | CCDSCCDS7791.1 CCDS CCDS7792.1 |
Suppression of tumorigenicity 5 is a protein that in humans is encoded by the ST5 gene. ST5 orthologs have been identified in nearly all mammals for which complete genome data are available. This gene was identified by its ability to suppress the tumorigenicity of Hela cells in nude mice. The protein encoded by this gene contains a C-terminal region that shares similarity with the Rab 3 family of small GTP binding proteins. This protein preferentially binds to the SH3 domain of c-Abl kinase, and acts as a regulator of MAPK1/ERK2 kinase, which may contribute to its ability to reduce the tumorigenic phenotype in cells. Three alternatively spliced transcript variants of this gene encoding distinct isoforms are identified. [provided by RefSeq].
May be involved in cytoskeletal organization and tumorgenicity. Isoform 1 seems to be involved in a signaling transduction pathway leading to activation of MAPK1/ERK2. Isoform 3 may block ERK2 activation stimulated by ABL1. Isoform 3 may alter cell morphology and cell growth.
Products for ST5 gene
Catalog | Product Name | Application | Company |
GFS:E01240 | suppression of tumorigenicity 5; ELISA kit | ELISA | n/a |
GFS:A01240 | suppression of tumorigenicity 5; Anti | ANTIBODIES | n/a |
GFS:P01240 | suppression of tumorigenicity 5; Protien | Protien | n/a |