Symbol: Name: ID: |
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 GFS:773 |
Gene name: | ST3GAL1 |
Chromosome: | 8q24.22 |
Previous Symbols: | SIAT4A |
Previous Names: | sialyltransferase 4A (beta-galactosidase alpha-2,3-sialytransferase) |
Aliases: | ST3O, SIATFL, ST3GalA.1 |
Name Aliases: | ST3Gal I |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:98304 | Rat Genome Database ID: | RGD:1309373 |
HGNC ID: | HGNC:10862 | RefSeq IDs: | NM_003033 |
Entrez Gene ID: | 6482 | Ensembl Gene ID: | ENSG00000008513 |
VEGA IDs: | UniProt ID: | Q11201 | |
UCSC ID: | uc003yuk.2 | OMIM ID: | 607187 |
Pubmed: | PMID10504389 PMID 7655169 | ||
CCDS IDs: | CCDSCCDS6373.1 |
The protein encoded by ST3GAL1 is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The encoded protein is normally found in the Golgi but can be proteolytically processed to a soluble form. Correct glycosylation of the encoded protein may be critical to its sialyltransferase activity. This protein, which is a member of glycosyltransferase family 29, can use the same acceptor substrates as does sialyltransferase 4B. Two transcript variants encoding the same protein have been found for this gene. Other transcript variants may exist, but have not been fully characterized yet. [provided by RefSeq].
It may be responsible for the synthesis of the sequence NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc- found on sugar chains O-linked to Thr or Ser and also as a terminal sequence on certain gangliosides. SIAT4A and SIAT4B sialylate the same acceptor substrates but exhibit different Km values.
Products for ST3GAL1 gene
Catalog | Product Name | Application | Company |
GFS:E00773 | ST3 beta-galactoside alpha-2,3-sialyltransferase 1; ELISA kit | ELISA | n/a |
GFS:A00773 | ST3 beta-galactoside alpha-2,3-sialyltransferase 1; Anti | ANTIBODIES | n/a |
GFS:P00773 | ST3 beta-galactoside alpha-2,3-sialyltransferase 1; Protien | Protien | n/a |