Symbol: Name: ID: |
ST14 suppression of tumorigenicity 14 (colon carcinoma) GFS:1233 |
Gene name: | ST14 |
Chromosome: | 11q24-q25 |
Previous Symbols: | PRSS14 |
Previous Names: | |
Aliases: | SNC19, HAI, MT-SP1, TMPRSS14 |
Name Aliases: | epithin, |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1338881 | Rat Genome Database ID: | RGD:69288 |
HGNC ID: | HGNC:11344 | RefSeq IDs: | NM_021978 |
Entrez Gene ID: | 6768 | Ensembl Gene ID: | ENSG00000149418 |
VEGA IDs: | UniProt ID: | Q9Y5Y6 | |
UCSC ID: | uc001qfw.2 | OMIM ID: | 606797 |
Pubmed: | PMID9925927 PMID 10373424 | ||
CCDS IDs: | CCDSCCDS8487.1 |
Suppression of tumorigenicity 14 (colon carcinoma), also known as ST14, is a human gene. The protein encoded by this gene is an epithelial-derived, integral membrane serine protease. This protease forms a complex with the Kunitz-type serine protease inhibitor, HAI-1, and is found to be activated by sphingosine 1-phosphate. This protease has been shown to cleave and activate hepatocyte growth factor/scattering factor, and urokinase plasminogen activator, which suggest the function of this protease as an epithelial membrane activator for other proteases and latent growth factors. The expression of this protease has been associated with breast, colon, prostate, and ovarian tumors, which implicates its role in cancer invasion, and metastasis. [provided by RefSeq]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Degrades extracellular matrix. Proposed to play a role in breast cancer invasion and metastasis. Exhibits trypsin-like activity as defined by cleavage of synthetic substrates with Arg or Lys as the P1 site.
Products for ST14 gene
Catalog | Product Name | Application | Company |
GFS:E01233 | suppression of tumorigenicity 14 (colon carcinoma); ELISA kit | ELISA | n/a |
GFS:A01233 | suppression of tumorigenicity 14 (colon carcinoma); Anti | ANTIBODIES | n/a |
GFS:P01233 | suppression of tumorigenicity 14 (colon carcinoma); Protien | Protien | n/a |