Symbol: Name: ID: |
SMC1B structural maintenance of chromosomes 1B GFS:1020 |
Gene name: | SMC1B |
Chromosome: | 22q13 |
Previous Symbols: | SMC1L2 |
Previous Names: | SMC1 (structural maintenance of chromosomes 1, yeast)-like 1, "SMC1 structural maintenance of chromosomes 1-like 2 (yeast)" |
Aliases: | bK268H5 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:2154049 | Rat Genome Database ID: | RGD:1308791 |
HGNC ID: | HGNC:11112 | RefSeq IDs: | NM_148674 |
Entrez Gene ID: | 27127 | Ensembl Gene ID: | ENSG00000077935 |
VEGA IDs: | OTTHUMG00000151334 | UniProt ID: | Q8NDV3 |
UCSC ID: | uc003bgc.2 | OMIM ID: | 608685 |
Pubmed: | PMID10591208 PMID 11564881 | ||
CCDS IDs: | CCDSCCDS43027.1 |
Structural maintenance of chromosomes protein 1B (SMC-1B) is a protein that in humans is encoded by the SMC1B gene. SMC1L2 belongs to a family of proteins required for chromatid cohesion and DNA recombination during meiosis and mitosis (3:Revenkova et al., 2001 [PubMed 11564881]).[supplied by OMIM].
Meiosis-specific component of cohesin complex. Required for the maintenance of meiotic cohesion, but not, or only to a minor extent, for its establishment. Contributes to axial element (AE) formation and the organization of chromatin loops along the AE. Plays a key role in synapsis, recombination and chromosome movements. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The meiosis-specific cohesin complex probably replaces mitosis specific cohesin complex when it dissociates from chromatin during prophase I (By similarity).
Products for SMC1B gene
Catalog | Product Name | Application | Company |
GFS:E01020 | structural maintenance of chromosomes 1B; ELISA kit | ELISA | n/a |
GFS:A01020 | structural maintenance of chromosomes 1B; Anti | ANTIBODIES | n/a |
GFS:P01020 | structural maintenance of chromosomes 1B; Protien | Protien | n/a |