Symbol: Name: ID: |
SMC1A structural maintenance of chromosomes 1A GFS:1019 |
Gene name: | SMC1A |
Chromosome: | Xp11.22-p11.21 |
Previous Symbols: | SMC1L1 |
Previous Names: | SMC1 (structural maintenance of chromosomes 1, yeast)-like 1, "SMC1 structural maintenance of chromosomes 1-like 1 (yeast)" |
Aliases: | DXS423E, KIAA0178, SB1.8, Smcb |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1344345 | Rat Genome Database ID: | RGD:61991 |
HGNC ID: | HGNC:11111 | RefSeq IDs: | NM_006306 |
Entrez Gene ID: | 8243 | Ensembl Gene ID: | ENSG00000072501 |
VEGA IDs: | OTTHUMG00000021614 | UniProt ID: | Q14683 |
UCSC ID: | uc004dsg.2 | OMIM ID: | 300040 |
Pubmed: | PMID7757074 | ||
CCDS IDs: | CCDSCCDS14352.1 |
Structural maintenance of chromosomes protein 1A is a protein that in humans is encoded by the SMC1A gene. Proper cohesion of sister chromatids is a prerequisite for the correct segregation of chromosomes during cell division. The cohesin multiprotein complex is required for sister chromatid cohesion. This complex is composed partly of two structural maintenance of chromosomes (SMC) proteins, SMC3 and either SMC1L2 or the protein encoded by this gene. Most of the cohesin complexes dissociate from the chromosomes before mitosis, although those complexes at the kinetochore remain. Therefore, the encoded protein is thought to be an important part of functional kinetochores. In addition, this protein interacts with BRCA1 and is phosphorylated by ATM, indicating a potential role for this protein in DNA repair. This gene, which belongs to the SMC gene family, is located in an area of the X-chromosome that escapes X inactivation. [provided by RefSeq]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Products for SMC1A gene
Catalog | Product Name | Application | Company |
GFS:E01019 | structural maintenance of chromosomes 1A; ELISA kit | ELISA | n/a |
GFS:A01019 | structural maintenance of chromosomes 1A; Anti | ANTIBODIES | n/a |
GFS:P01019 | structural maintenance of chromosomes 1A; Protien | Protien | n/a |