Symbol: Name: ID: |
SLC9A3R2 solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2 GFS:990 |
Gene name: | SLC9A3R2 |
Chromosome: | 16p13.3 |
Previous Symbols: | |
Previous Names: | solute carrier family 9 (sodium/hydrogen exchanger), isoform 3 regulatory factor 2, "solute carrier family 9 (sodium/hydrogen exchanger), isoform 3 regulator 2" |
Aliases: | SIP-1, TKA-1, NHERF-2, E3KARP |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1890662 | Rat Genome Database ID: | |
HGNC ID: | HGNC:11076 | RefSeq IDs: | NM_001130012 |
Entrez Gene ID: | 9351 | Ensembl Gene ID: | ENSG00000065054 |
VEGA IDs: | UniProt ID: | Q15599 | |
UCSC ID: | uc002coi.2 | OMIM ID: | 606553 |
Pubmed: | PMID9054412 PMID 9671706 | ||
CCDS IDs: | CCDSCCDS45382.1 CCDS CCDS45383.1 |
Sodium-hydrogen exchange regulatory cofactor NHE-RF2 (NHERF-2) also known as tyrosine kinase activator protein 1 (TKA-1) or SRY-interacting protein 1 (SIP-1) is a protein that in humans is encoded by the SLC9A3R2 (solute carrier family 9 isoform A3 regulatory factor 2) gene. NHE3 (SLC9A3; MIM 182307) is a sodium/hydrogen exchanger in the brush border membrane of the proximal tubule, small intestine, and colon that plays a major role in transepithelial sodium absorption. SLC9A3R2, as well as SLC9A3R1 (MIM 604990) and protein kinase A phosphorylation, may play a role in NHE3 regulation.[supplied by OMIM].
Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. May also act as scaffold protein in the nucleus.
Products for SLC9A3R2 gene
Catalog | Product Name | Application | Company |
GFS:E00990 | solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2; ELISA kit | ELISA | n/a |
GFS:A00990 | solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2; Anti | ANTIBODIES | n/a |
GFS:P00990 | solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2; Protien | Protien | n/a |