Symbol: Name: ID: |
SLC16A2 solute carrier family 16, member 2 (monocarboxylic acid transporter 8) GFS:833 |
Gene name: | SLC16A2 |
Chromosome: | Xq13.2 |
Previous Symbols: | DXS128, AHDS, MRX22 |
Previous Names: | solute carrier family 16 (monocarboxylic acid transporters), member 2 (putative transporter), "Allan-Herndon-Dudley syndrome", "solute carrier family 16 (monocarboxylic acid transporters), member 2", "mental retardation, X-linked 22" |
Aliases: | XPCT, MCT8, MCT7 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1203732 | Rat Genome Database ID: | RGD:628608 |
HGNC ID: | HGNC:10923 | RefSeq IDs: | NM_006517 |
Entrez Gene ID: | 6567 | Ensembl Gene ID: | ENSG00000147100 |
VEGA IDs: | OTTHUMG00000021857 | UniProt ID: | P36021 |
UCSC ID: | uc004ebt.2 | OMIM ID: | 300095 |
Pubmed: | PMID7981683 PMID 12871948 PMID 15889350 | ||
CCDS IDs: | CCDSCCDS14426.1 |
Monocarboxylate transporter 8 (MCT8) is a protein that in humans is encoded by the SLC16A2 gene. This gene encodes an integral membrane protein transporter of thyroid hormone; specifically, cellular importation of thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). This gene is expressed in many tissues including brain, heart, placenta, lung, kidney, skeletal muscle, and liver. This gene likely plays an important role in the development of the central nervous system. Loss of function mutations in this gene are associated with psychomotor retardation in males while females exhibit no neurological defects and more moderate thyroid-deficient phenotypes. This gene is subject to X-chromosome inactivation. [provided by RefSeq]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Very active and specific thyroid hormone transporter. Stimulates cellular uptake of thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine. Does not transport Leu, Phe, Trp or Tyr (By similarity).
Products for SLC16A2 gene
Catalog | Product Name | Application | Company |
GFS:E00833 | solute carrier family 16, member 2 (monocarboxylic acid transporter 8); ELISA kit | ELISA | n/a |
GFS:A00833 | solute carrier family 16, member 2 (monocarboxylic acid transporter 8); Anti | ANTIBODIES | n/a |
GFS:P00833 | solute carrier family 16, member 2 (monocarboxylic acid transporter 8); Protien | Protien | n/a |