Symbol: Name: ID: |
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2 GFS:817 |
Gene name: | SLC11A2 |
Chromosome: | 12q13 |
Previous Symbols: | NRAMP2 |
Previous Names: | |
Aliases: | DCT1, DMT1 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1345279 | Rat Genome Database ID: | RGD:3684 |
HGNC ID: | HGNC:10908 | RefSeq IDs: | NM_000617 |
Entrez Gene ID: | 4891 | Ensembl Gene ID: | ENSG00000110911 |
VEGA IDs: | UniProt ID: | P49281 | |
UCSC ID: | uc001rxi.2 | OMIM ID: | 600523 |
Pubmed: | PMID7613023 | ||
CCDS IDs: | CCDSCCDS8805.1 |
SLC11A2 encodes a member of the solute carrier family 11 protein family. The product of this gene transports divalent metals and is involved in iron absorption. Mutations in this gene are associated with hypochromic microcytic anemia with iron overload. A related solute carrier family 11 protein gene is located on chromosome 2. Multiple transcript variants encoding different isoforms have been found for this gene.
Important in metal transport, in particular iron. Can also transport manganese, cobalt, cadmium, nickel, vanadium and lead. Involved in apical iron uptake into duodenal enterocytes. Involved in iron transport from acidified endosomes into the cytoplasm of erythroid precursor cells. May play an important role in hepatic iron accumulation and tissue iron distribution.
Products for SLC11A2 gene
Catalog | Product Name | Application | Company |
GFS:E00817 | solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2; ELISA kit | ELISA | n/a |
GFS:A00817 | solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2; Anti | ANTIBODIES | n/a |
GFS:P00817 | solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2; Protien | Protien | n/a |