Symbol: Name: ID: |
SLC8A3 solute carrier family 8 (sodium/calcium exchanger), member 3 GFS:984 |
Gene name: | SLC8A3 |
Chromosome: | 14q24.1 |
Previous Symbols: | |
Previous Names: | |
Aliases: | NCX3 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:107976 | Rat Genome Database ID: | RGD:620197 |
HGNC ID: | HGNC:11070 | RefSeq IDs: | NM_001130417 |
Entrez Gene ID: | 6547 | Ensembl Gene ID: | ENSG00000100678 |
VEGA IDs: | OTTHUMG00000152342 | UniProt ID: | P57103 |
UCSC ID: | uc001xly.2 | OMIM ID: | 607991 |
Pubmed: | PMID8798769 | ||
CCDS IDs: | CCDSCCDS9799.1 CCDS CCDS9800.1 CCDS CCDS35498.1 CCDS CCDS41967.1 CCDS CCDS45131.1 |
SLC8A3 encodes a member of the sodium/calcium exchanger integral membrane protein family. Three mammalian isoforms in family 8 have been identified. Na+/Ca2+ exchange proteins are involved in maintaining Ca2+ homeostasis in a wide variety of cell types. The protein is regulated by intracellular calcium ions and is found in both the plasma membrane and intracellular organellar membranes, where exchange of Na+ for Ca2+ occurs in an electrogenic manner. Alternative splicing has been observed for this gene and multiple variants have been described. [provided by RefSeq].
The Na+/Ca2+ exchanger (NCX) is a low affinity, high capacitance calcium antiporter membrane protein that functions to regulate intracellular calcium concentrations. It is located on the plasma, mitochondrial and endoplasmic reticular membranes of excitable cells. Using the electrochemical gradient of Na+, one Ca2+ ion is transported in exchange for three Na+ ions. The Na+/Ca2+ exchanger compliments the high affinity, low capacitance Ca2+-ATPase and together, they are involved in a variety of cellular functions including control of neurosecretion, relaxation of cardiac muscle, maintenance of intracellular Ca2+ stores in the endoplasmic and sarcoplasmic reticuli and excitation-relaxation coupling. Under normal physiological conditions, Na+/Ca2+ exchangers export Ca+ from the cell. However, under cellular stress, such as excitotoxicity, they can switch to 'reverse mode', which has a protective effect.
Products for SLC8A3 gene
Catalog | Product Name | Application | Company |
GFS:E00984 | solute carrier family 8 (sodium/calcium exchanger), member 3; ELISA kit | ELISA | n/a |
GFS:A00984 | solute carrier family 8 (sodium/calcium exchanger), member 3; Anti | ANTIBODIES | n/a |
GFS:P00984 | solute carrier family 8 (sodium/calcium exchanger), member 3; Protien | Protien | n/a |