Symbol: Name: ID: |
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 GFS:981 |
Gene name: | SLC8A1 |
Chromosome: | 2p23-p22 |
Previous Symbols: | NCX1 |
Previous Names: | |
Aliases: | |
Name Aliases: | Na+/Ca++ exchanger |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:107956 | Rat Genome Database ID: | |
HGNC ID: | HGNC:11068 | RefSeq IDs: | NM_001112800 |
Entrez Gene ID: | 6546 | Ensembl Gene ID: | ENSG00000183023 |
VEGA IDs: | OTTHUMG00000102183 | UniProt ID: | P32418 |
UCSC ID: | uc002rrx.2 | OMIM ID: | 182305 |
Pubmed: | PMID1559714 | ||
CCDS IDs: | CCDSCCDS1806.1 CCDS CCDS46264.1 CCDS CCDS46265.1 |
In cardiac myocytes, Ca(2+) concentrations alternate between high levels during contraction and low levels during relaxation. The increase in Ca(2+) concentration during contraction is primarily due to release of Ca(2+) from intracellular stores. However, some Ca(2+) also enters the cell through the sarcolemma (plasma membrane). During relaxation, Ca(2+) is sequestered within the intracellular stores. To prevent overloading of intracellular stores, the Ca(2+) that entered across the sarcolemma must be extruded from the cell. The Na(+)-Ca(2+) exchanger is the primary mechanism by which the Ca(2+) is extruded from the cell during relaxation. In the heart, the exchanger may play a key role in digitalis action. The exchanger is the dominant mechanism in returning the cardiac myocyte to its resting state following excitation.[supplied by OMIM].
Rapidly transports Ca(2+) during excitation-contraction coupling. Ca(2+) is extruded from the cell during relaxation so as to prevent overloading of intracellular stores.
Products for SLC8A1 gene
Catalog | Product Name | Application | Company |
GFS:E00981 | solute carrier family 8 (sodium/calcium exchanger), member 1; ELISA kit | ELISA | n/a |
GFS:A00981 | solute carrier family 8 (sodium/calcium exchanger), member 1; Anti | ANTIBODIES | n/a |
GFS:P00981 | solute carrier family 8 (sodium/calcium exchanger), member 1; Protien | Protien | n/a |