Symbol: Name: ID: |
SLC7A7 solute carrier family 7 (cationic amino acid transporter, y+ system), member 7 GFS:978 |
Gene name: | SLC7A7 |
Chromosome: | 14q11.2 |
Previous Symbols: | LPI |
Previous Names: | |
Aliases: | y+LAT-1 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1337120 | Rat Genome Database ID: | RGD:619902 |
HGNC ID: | HGNC:11065 | RefSeq IDs: | NM_001126105 |
Entrez Gene ID: | 9056 | Ensembl Gene ID: | ENSG00000155465 |
VEGA IDs: | OTTHUMG00000028692 | UniProt ID: | Q9UM01 |
UCSC ID: | uc001wgs.3 | OMIM ID: | 603593 |
Pubmed: | PMID9829974 | ||
CCDS IDs: | CCDSCCDS9574.1 |
Y+L amino acid transporter 1 is a protein that in humans is encoded by the SLC7A7 gene. The protein encoded by this gene is the light subunit of a cationic amino acid transporter. This sodium-independent transporter is formed when the light subunit encoded by this gene dimerizes with the heavy subunit transporter protein SLC3A2. This transporter is found in epithelial cell membranes where it transfers cationic and large neutral amino acids from the cell to the extracellular space. Defects in this gene are a cause of lysinuric protein intolerance (LPI). Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq].
Involved in the sodium-independent uptake of dibasic amino acids and sodium-dependent uptake of some neutral amino acids. Requires co-expression with SLC3A2/4F2hc to mediate the uptake of arginine, leucine and glutamine. Plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine. Involved in the transport of L-arginine in monocytes.
Products for SLC7A7 gene
Catalog | Product Name | Application | Company |
GFS:E00978 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 7; ELISA kit | ELISA | n/a |
GFS:A00978 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 7; Anti | ANTIBODIES | n/a |
GFS:P00978 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 7; Protien | Protien | n/a |