Symbol: Name: ID: |
SLC6A6 solute carrier family 6 (neurotransmitter transporter, taurine), member 6 GFS:964 |
Gene name: | SLC6A6 |
Chromosome: | 3p26-p24 |
Previous Symbols: | |
Previous Names: | |
Aliases: | TAUT |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:98488 | Rat Genome Database ID: | RGD:61912 |
HGNC ID: | HGNC:11052 | RefSeq IDs: | NM_001134367 |
Entrez Gene ID: | 6533 | Ensembl Gene ID: | ENSG00000131389 |
VEGA IDs: | OTTHUMG00000155525 | UniProt ID: | P31641 |
UCSC ID: | uc010heg.2 | OMIM ID: | 186854 |
Pubmed: | PMID8010975 PMID 8382624 | ||
CCDS IDs: | CCDSCCDS33705.1 CCDS CCDS46765.1 |
Taurine (2-aminoethanesulfonic acid) is a major intracellular amino acid in mammals. It is involved in a number of important physiologic processes, including bile acid conjugation in hepatocytes, modulation of calcium flux and neural excitability, osmoregulation, detoxification, and membrane stabilization. The cells of most organisms respond to hypertonicity by the intracellular accumulation of high concentrations of small organic solutes (osmolytes) that, in contrast to high concentrations of electrolytes, do not perturb the function of macromolecules. The renal medulla is normally the only tissue in mammals that undergoes wide shifts in tonicity. Its hypertonicity when the kidney is excreting a concentrated urine is fundamental to water conservation. The taurine content of the renal medulla of rats infused with 5% NaCl is higher than that in controls, suggesting that taurine behaves as an osmolyte in the renal medulla. Indeed, taurine functions as an osmolyte in Madin-Darby canine kidney (MDCK) cells. When MDCK cells cultured in isotonic medium are switched to hypertonic medium, their content of taurine doubles through the taking up of taurine from the medium. Taurine transport in these cells is dependent on sodium and chloride ions and is localized primarily in the basolateral plasma membrane (summary by Uchida et al., 1992 [PubMed 1518851]).[supplied by OMIM]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Products for SLC6A6 gene
Catalog | Product Name | Application | Company |
GFS:E00964 | solute carrier family 6 (neurotransmitter transporter, taurine), member 6; ELISA kit | ELISA | n/a |
GFS:A00964 | solute carrier family 6 (neurotransmitter transporter, taurine), member 6; Anti | ANTIBODIES | n/a |
GFS:P00964 | solute carrier family 6 (neurotransmitter transporter, taurine), member 6; Protien | Protien | n/a |