Symbol: Name: ID: |
SLC6A4 solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 GFS:962 |
Gene name: | SLC6A4 |
Chromosome: | 17q11.2 |
Previous Symbols: | HTT |
Previous Names: | |
Aliases: | 5-HTT |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:96285 | Rat Genome Database ID: | RGD:3714 |
HGNC ID: | HGNC:11050 | RefSeq IDs: | NM_001045 |
Entrez Gene ID: | 6532 | Ensembl Gene ID: | ENSG00000108576 |
VEGA IDs: | OTTHUMG00000132751 | UniProt ID: | P31645 |
UCSC ID: | uc002hey.3 | OMIM ID: | 182138 |
Pubmed: | PMID7681602 | ||
CCDS IDs: | CCDSCCDS11256.1 |
The serotonin transporter (SERT) is a monoamine transporter protein. This gene encodes an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. The encoded protein terminates the action of serotonin and recycles it in a sodium-dependent manner. This protein is a target of psychomotor stimulants, such as amphetamines and cocaine, and is a member of the sodium:neurotransmitter symporter family. A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake and may play a role in sudden infant death syndrome, aggressive behavior in Alzheimer disease patients, and depression-susceptibility in people experiencing emotional trauma. [provided by RefSeq]. Sequence Note: The RefSeq transcript and protein were derived from transcript and genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Serotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin molecules from the synaptic cleft back into the pre-synaptic terminal for re-utilization. Plays a key role in mediating regulation of the availability of serotonin to other receptors of serotonergic systems. Terminates the action of serotonin and recycles it in a sodium-dependent manner.
Products for SLC6A4 gene
Catalog | Product Name | Application | Company |
GFS:E00962 | solute carrier family 6 (neurotransmitter transporter, serotonin), member 4; ELISA kit | ELISA | n/a |
GFS:A00962 | solute carrier family 6 (neurotransmitter transporter, serotonin), member 4; Anti | ANTIBODIES | n/a |
GFS:P00962 | solute carrier family 6 (neurotransmitter transporter, serotonin), member 4; Protien | Protien | n/a |