Symbol: Name: ID: |
SLC6A3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 GFS:960 |
Gene name: | SLC6A3 |
Chromosome: | 5p15.3 |
Previous Symbols: | DAT1 |
Previous Names: | |
Aliases: | DAT |
Name Aliases: | dopamine transporter |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:94862 | Rat Genome Database ID: | RGD:3715 |
HGNC ID: | HGNC:11049 | RefSeq IDs: | NM_001044 |
Entrez Gene ID: | 6531 | Ensembl Gene ID: | ENSG00000142319 |
VEGA IDs: | OTTHUMG00000131016 | UniProt ID: | Q01959 |
UCSC ID: | uc003jck.2 | OMIM ID: | 126455 |
Pubmed: | PMID1406597 | ||
CCDS IDs: | CCDSCCDS3863.1 |
The dopamine transporter (also dopamine active transporter, DAT, SLC6A3) is a membrane-spanning protein that pumps the neurotransmitter dopamine out of the synapse back into cytosol, from which other transporters sequester DA and NE into vesicles for later storage and release. Dopamine reuptake via DAT provides the primary mechanism through which dopamine is cleared from synapses except in the prefrontal cortex, where dopamine uptake via the norepinephrine transporter plays that role.
This gene encodes a dopamine transporter which is a member of the sodium- and chloride-dependent neurotransmitter transporter family. The 3' UTR of this gene contains a 40 bp tandem repeat, referred to as a variable number tandem repeat or VNTR, which can be present in 3 to 11 copies. Variation in the number of repeats is associated with idiopathic epilepsy, attention-deficit hyperactivity disorder, dependence on alcohol and cocaine, susceptibility to Parkinson disease and protection against nicotine dependence. Sequence Note: Variation in the number of 40 bp repeats in the 3' UTR of this gene has been reported with a normal range of 3 to 11 repeats. The Reference Sequence contains 10 copies of these repeats. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Amine transporter. Terminates the action of dopamine by its high affinity sodium-dependent reuptake into presynaptic terminals.
Products for SLC6A3 gene
Catalog | Product Name | Application | Company |
GFS:E00960 | solute carrier family 6 (neurotransmitter transporter, dopamine), member 3; ELISA kit | ELISA | n/a |
GFS:A00960 | solute carrier family 6 (neurotransmitter transporter, dopamine), member 3; Anti | ANTIBODIES | n/a |
GFS:P00960 | solute carrier family 6 (neurotransmitter transporter, dopamine), member 3; Protien | Protien | n/a |