Symbol: Name: ID: |
SLC6A12 solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12 GFS:956 |
Gene name: | SLC6A12 |
Chromosome: | 12p13 |
Previous Symbols: | |
Previous Names: | |
Aliases: | BGT-1 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:95628 | Rat Genome Database ID: | RGD:620255 |
HGNC ID: | HGNC:11045 | RefSeq IDs: | NM_001122847 |
Entrez Gene ID: | 6539 | Ensembl Gene ID: | ENSG00000111181 |
VEGA IDs: | OTTHUMG00000090309 | UniProt ID: | P48065 |
UCSC ID: | uc001qib.2 | OMIM ID: | 603080 |
Pubmed: | PMID7589472 | ||
CCDS IDs: | CCDSCCDS8501.1 |
Transports betaine and GABA. May have a role in regulation of GABAergic transmission in the brain through the reuptake of GABA into presynaptic terminals, as well as in osmotic regulation.
GABA transporters are sodium- and chloride-dependent members of the solute carrier family 6 (SLC6) that mediate the rapid removal of GABA and maintain low extracellular levels. Four 12-TM domain transporters (GAT-1, GAT-2, GAT-3 and BGT-1) have been identified and localized to neurons and glia. While GAT-1, GAT-2, GAT-3 and BGT-1 bind GABA with varying affinities, they share structural motifs including 12-TM domains, extracellular glycosylation sites and intracellular consensus sites for phosphorylation. A vesicular transporter (VGAT) has also been identified. This member of the SCL32 family is both structurally and functionally distinct, containing 10-TM domains and being found in GABAergic and glycinergic neurons. Some anticonvulsants have been reported to act upon the GABA transporters. There is evidence to suggest that GABA transporters are linked to epilepsy, affective disorders and schizophrenia.
Products for SLC6A12 gene
Catalog | Product Name | Application | Company |
GFS:E00956 | solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12; ELISA kit | ELISA | n/a |
GFS:A00956 | solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12; Anti | ANTIBODIES | n/a |
GFS:P00956 | solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12; Protien | Protien | n/a |