Symbol: Name: ID: |
SLC4A4 solute carrier family 4, sodium bicarbonate cotransporter, member 4 GFS:942 |
Gene name: | SLC4A4 |
Chromosome: | 4q21 |
Previous Symbols: | SLC4A5 |
Previous Names: | |
Aliases: | NBC1, HNBC1, NBC2, pNBC, hhNMC |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1927555 | Rat Genome Database ID: | RGD:68936 |
HGNC ID: | HGNC:11030 | RefSeq IDs: | NM_001098484 |
Entrez Gene ID: | 8671 | Ensembl Gene ID: | ENSG00000080493 |
VEGA IDs: | OTTHUMG00000129907 | UniProt ID: | Q9Y6R1 |
UCSC ID: | uc010iic.2 | OMIM ID: | 603345 |
Pubmed: | PMID9235899 PMID 9651366 | ||
CCDS IDs: | CCDSCCDS3549.1 CCDS CCDS43236.1 CCDS CCDS47071.1 |
Electrogenic sodium bicarbonate cotransporter 1 is a protein that in humans is encoded by the SLC4A4 gene. Sodium bicarbonate cotransporters (NBCs) mediate the coupled movement of sodium and bicarbonate ions across the plasma membrane of many cells. This is an electrogenic process with an apparent stoichiometry of 3 bicarbonate ions per sodium ion. Sodium bicarbonate cotransport is involved in bicarbonate secretion/absorption and intracellular pH regulation. Romero and Boron (1999) reviewed NBCs. Soleimani and Burnham (2000) reviewed NBCs and their regulation in physiologic and pathophysiologic states.[supplied by OMIM].
This gene encodes a sodium bicarbonate cotransporter (NBC) involved in the regulation of bicarbonate secretion and absorption and intracellular pH. Mutations in this gene are associated with proximal renal tubular acidosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].
Electrogenic sodium/bicarbonate cotransporter with a Na(+):HCO3(-) stoichiometry varying from 1:2 to 1:3. May regulate bicarbonate influx/efflux at the basolateral membrane of cells and regulate intracellular pH.
Products for SLC4A4 gene
Catalog | Product Name | Application | Company |
GFS:E00942 | solute carrier family 4, sodium bicarbonate cotransporter, member 4; ELISA kit | ELISA | n/a |
GFS:A00942 | solute carrier family 4, sodium bicarbonate cotransporter, member 4; Anti | ANTIBODIES | n/a |
GFS:P00942 | solute carrier family 4, sodium bicarbonate cotransporter, member 4; Protien | Protien | n/a |